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A 45-year-old woman developed opsoclonus,myoclonus,and severe truncal and gait ataxia.Serum and CSF contained IgG antibodies that appear to be identical to"anti-Ri"antibodies associated with paraneoplastic opsoclonus and ataxia.The patient had a fluctuating course with exacerbations that responded well to corticosteroids and later by cyclophosphamide.Her anti- Ri antibody titer has declined significantly but still remains high.After more than 3 years of follow-up,no neoplasm has been detected. |
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